Holoptelea integrifolia is an indigenous medicinal plant of India has traditionally used in the treatment of kidney diseases, urinary disorder and jaundice. The aim of the present study is to investigate the nephroprotective activity of ethanol and aqueous extract of leaves of Holoptelea integrifolia in acetaminophen induced acute renal failure albino rat’s model at dose level of 250 mg/kg and 500 mg/kg. Result observed in biochemical studies showed that there is an increase in the levels of serum urea and creatinine along with an increase in the body weight and reduction in the levels of uric acid in acetaminophen induced. These values are retrieved significantly by treatment with Holoptelea integrifolia ethanol extracts at 500 mg/kg dose. Apart from these, changes in histoarchitecture of renal tissues also reveal the protective nature of the ethanol extracts against acetaminophen induced necrotic damage of renal tissues. The findings suggest that the ethanol extract of Holoptelea integrifolia possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by acetaminophen.
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